DebaryOmics: an integrative –omics study to understand the halophilic behaviour of Debaryomyces hansenii

Abstract

This came from one of the collaborations I worked on during my postdoc. Debaryomyces hansenii is a non-conventional yeast of industrial interest, mainly due to its high halotolerance (resistance to high salt levels). To better understand said tolerance, here we performed chemostat cultivations of D. hansenii in the presence of different salts, and studied the transcriptomic and (phospho)proteomic responses under each condition. I mainly provided support on the transcriptomics analyses. The results show that sodium and potassium trigger different responses at both gene expression and protein activity levels. In particular, a novel and yet uncharacterized cation transporter was found associated to the response to high sodium levels.

Benjamín J. Sánchez

Senior Scientist

Biology, math, programming, running, and many other fun things